Tumor Necrosis Factor Receptor Type 1, human recombinant (rHuTNFR1)

Tumor Necrosis Factor Receptor Type 1, human recombinant (rHuTNFR1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97323.5 5 µg - -

3 - 10 business days*

94.00€
97323.20 20 µg - -

3 - 10 business days*

208.00€
97323.1 1 mg - -

3 - 10 business days*

3,952.00€
 
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule... more
Product information "Tumor Necrosis Factor Receptor Type 1, human recombinant (rHuTNFR1)"
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. (www.uniprot.org) TNFR1 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 162 amino acids and having a total molecular mass of 18.2 kDa. TNFR1 Human Recombinant is purified by proprietary chromatographic techniques. TNFR1 belongs to the TNF-receptor superfamily. TNFR1 is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II, which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors seem to increase as a result of shedding of the extracellular domains of the membrane bound receptors. TNF-a, TNFR1 and TNFR2 have roles in cellular differentiation. TNFR1 and TNFR2 function in cell type-specific renal injury. TNFR1 is capable of signaling both cell survival and apoptosis. TNFR1-induced apoptosis requires 2 sequential signaling complexes. TNFR1 is capable of activating NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Oxidative stress promotes TNFR1 and TNFR2 self-interaction, ligand-independent and enhanced ligand-dependent TNF signaling.
Keywords: Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-R1, TNF-RI, TNFR-I, p60, p55, CD120a, TNFRSF1A, TNFAR, TNFR1, FPF, TBP1, TNF-R, p55-R, TNFR55, TNFR60, TNF-R-I, TNF-R55, MGC
Supplier: Biomol GmbH
Supplier-Nr: 97323

Properties

Application: Bioassay
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 18200 D
Purity: >97%
Format: Purified

Database Information

KEGG ID : K03158 | Matching products
UniProt ID : P19438 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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