31 products were found matching "T8250-13F"!

TGFb1 (transforming growth factor-beta1) is a family of multifunctional 25kD proteins. TGFb1 was originally identified for its ability to induce the growth of normal rodent fibroblasts in soft agar. It is now known that TGFb1 is a potent growth inhibitor of many normal and transformed cell lines. It regulates normal...

Human Transforming Growth Factor beta1 (TGF-beta1) is stimulatory for cells of mesenchymal origin and inhibitory for cells of epithelial or neuroectodermal origin. Mature TGF-beta1 is a disulfide-linked homodimer of two chains composed of 112aa residues each. There is a 70% homology between human TGF-beta1 and human...

TGF-b is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-b1 complex is composed of three components: mature TGF-b1 dimer, latency associated peptide, and latent TGF-b binding protein (LTBP). The cDNAs for four binding proteins (LTBP-1,-2,-3 and-4) have now been cloned., ,...

Applications:, Suitable for Direct ELISA. Will bind very well to Protein A in a buffer (PBS) containing high salt concentration (3M sodium chloride). Other applications not tested. Recommended Dilution: Direct ELISA: 1:10,000 dilution will yield 0.7 O.D within 10 minutes, using alkaline phosphatase goat anti-mouse...

TGF-beta is secreted by cells in the form of an inactive complex. This complex consists of TGF-beta associated non-covalently with a protein designated the latency associated peptide (LAP). TGf-beta and LAP represent components of a pro-peptide that is cleaved in a post-golgi compartment prior to secretion. LAP and...

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic...

TGF-b RI, also known as activin-like kinase 5 (ALK-5), is a 55kD type I transmembrane serine/threonine receptor kinase. It is ubiquitously expressed and forms a functional heterotetrameric signaling TGF-b receptor complex with TGF-b RII. The aa sequence of human TGF-b RI extracellular domain is 91%, 90%, 91% and 93%...

Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB...

Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB...

MART-1 (also known as Melan-A) is a melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, Tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is...

Transforming growth factor-beta (TGF-beta) family of proteins has potent hematopoietic regulatory properties ranging from effects on the growth and differentiation of primitive stem cells to the differentiated functions of mature cells. Applications: Suitable for use in Western Blot, ELISA, Neutralization and...

Applications: , Suitable for use in Western Blot and ELISA. Other applications not tested. Recommended Dilution: Western Blot: 5-20ng/ml will allow visualization of 100ng/lane of TGF-beta. Hybridoma: Sp2/0-Ag14 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for...