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Item number: Cay16292-25

Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM)...

Keywords:	GSK1120212, JTP-74057,...
Application:	MEK1 / MEK2 inhibitor
CAS	871700-17-3
MW:	615.4 D

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