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Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and... more
Product information "Tolterodine (tartrate)"
Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively). It reduces intracellular calcium mobilization induced by carbachol (carbamoylcholine, Cay-14486) in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively). Tolterodine inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively). Formulations containing tolterodine have been used in the treatment of overactive bladder.Formal Name: 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol, 2R,3R-dihydroxybutanedioate. CAS Number: 124937-52-6. Synonyms: PNU 200583E. Molecular Formula: C22H31NO . C4H6O6. Formula Weight: 475.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 284 nm. SMILES: OC1=C([C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C)C=C(C)C=C1.O[C@H]([C@@H](O)C(O)=O)C(O)=O. InChi Code: InChI=1S/C22H31NO.C4H6O6/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24,5-1(3(7)8)2(6)4(9)10/h6-12,15-17,20,24H,13-14H2,1-5H3,1-2,5-6H,(H,7,8)(H,9,10)/t20-,/m1./s1. InChi Key: TWHNMSJGYKMTRB-VEIFNGETSA-N.
Keywords: | PNU 200583E, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol, 2R,3R-dihydroxybutanedioate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 15027 |
Properties
Application: | Muscarinic (M) receptor antagonist |
MW: | 475.6 D |
Formula: | C22H31NO . C4H6O6 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 124937-52-6| Matching products |
KEGG ID : | K04129 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H301, H361, H401, H411 |
P Phrases: | P201, P202, P264, P270, P273, P280, P301+310, P308+313, P321, P330, P391, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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