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Tiotropium (bromide)
Tiotropium (bromide)

Item number: Cay15773-5

Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors). It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled...
Keywords: BA 679BR,...
Application: Muscarinic cholinergic receptor antagonist
CAS 136310-93-5
MW: 472.4 D
From 98.00€ *
Review
IOX2
IOX2

Item number: Cay11573-10

IOX2 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2, IC50 = 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s > 100 µM). IOX2 is active in cells, inhibiting HIF-1alpha hydroxylation in RCC4 cells at 50 µM. See the...
Keywords: N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine
Application: PHD2 inhibitor
CAS 931398-72-0
MW: 352.3 D
From 92.00€ *
Review
CAY10681
CAY10681

Item number: Cay15573-10

Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-kappaB in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-kappaB signaling. It potently binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53. CAY10681 also inhibits phosphorylation of...
Keywords: 4-(4-bromophenyl)-4,5-dihydro-5-[3-(1H-imidazol-1-yl)propyl]-3-phenyl-1-(phenylmethyl)-pyrrolo[3,4-c]pyrazol-6(1H)-one
Application: p53-MDM2 interaction / NF-kappaB signaling modulator
CAS 1542066-69-2
MW: 552.5 D
From 98.00€ *
Review