Tin(IV) Protoporphyrin IX Chloride

Tin(IV) Protoporphyrin IX Chloride
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16375-5 5 mg -

6 - 10 business days*

66.00€
Cay16375-10 10 mg -

6 - 10 business days*

123.00€
Cay16375-25 25 mg -

6 - 10 business days*

290.00€
Cay16375-50 50 mg -

6 - 10 business days*

509.00€
 
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized... more
Product information "Tin(IV) Protoporphyrin IX Chloride"
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Cay-17161). While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. Tin(IV) protoporphyrin IX chloride is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). Tin(IV) protoporphyrin IX chloride prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. Tin(IV) protoporphyrin IX chloride is commonly used as a tool to study the role of HO-1 activity in cells and in animals.Formal Name: (OC-6-13)-dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24]-stannate(2-), dihydrogen. CAS Number: 14325-05-4. Synonyms: NSC 267099, SnPPIX. Molecular Formula: C34H30Cl2N4O4Sn . 2H. Formula Weight: 750.3. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 0.5 mg/ml. lambdamax: 405, 541, 579 nm. SMILES: [O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Sn+4]35([Cl-])([Cl-])[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+]. InChi Code: InChI=1S/C34H34N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25,,,/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42),2*1H,/q,,,+4/p-4/b25-13-,26-. InChi Key: HDGCWLZQBOZSGG-UHEVNVKKSA-J.
Keywords: NSC 267099, SnPPIX, (OC-6-13)-dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24]-stannate(2-), dihydrogen
Supplier: Cayman Chemical
Supplier-Nr: 16375

Properties

Application: HO-1 inhibitor
MW: 750.3 D
Formula: C34H30Cl2N4O4Sn . 2H
Format: Crystalline Solid

Database Information

CAS : 14325-05-4| Matching products
KEGG ID : K00510 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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