Tim-3 (human):Fc (human) (rec.)

Tim-3 (human):Fc (human) (rec.)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-210T3-C100 100 µg - -

3 - 9 business days*

523.00€
 
The extracellular domain of human Tim-3 (aa 22-200) is fused to the N-terminus of the Fc region... more
Product information "Tim-3 (human):Fc (human) (rec.)"
The extracellular domain of human Tim-3 (aa 22-200) is fused to the N-terminus of the Fc region of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerated diabetes in nonobese diabetic mice, caused hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevented acquisition of transplantation tolerance induced by costimulation blockade.
Keywords: TIM3, TIM-3, TIMD-3, HAVCR2, HAVcr-2, T-cell membrane protein 3, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-210T3

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: human
Purity: >98%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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