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Thyroid Hormone Receptor Antagonist (1-850)

Item number: Cay17248-1

Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRalpha and TRbeta (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TRalpha in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor...

Keywords:	2-[1-(4-nitrophenyl)-4-piperidinylidene]-acetic acid-2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
Application:	THRB / THRA antagonist
CAS	251310-57-3
MW:	463.4 D

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