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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TARC rat recombinant produced in E. coli is a non-glycosylated, polypeptide chain containing 70... more
Product information "Thymus and Activation Regulated Chemokine (CCL17), rat recombinant (rrTARC)"
TARC rat recombinant produced in E. coli is a non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 8.1 kDa. TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1a, MIP-1b, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. The biological activity of recombinant rat TARC is determined by its ability to chemoattract human T-Lymphocytes using a concentration range of 1.0 - 10.0 ng/ml.
Keywords: | C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273. |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97624 |
Properties
Application: | Cell culture |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | rat |
MW: | 8100 D |
Purity: | >97% |
Format: | Lyophilized |
Database Information
KEGG ID : | K21083 | Matching products |
UniProt ID : | Q9ERE0 | Matching products |
Gene ID | GeneID 117518 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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