Thymus and Activation Regulated Chemokine (CCL17), His Tag, human recombinant (rHuTARC-His)

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. (www.uniprot.org) Human recombinant TARC produced in E.coli is a non-glycosylated polypeptide chain containing 92 amino acids (fragment 24-94) and having a molecular mass of 10.3 kDa. The TARC is fused to 20 amino acid His-Tag at N-terminus. TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T-cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T-cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T-cell development in thymus as well as in trafficking and activation of mature T-cells.