Thioperamide (maleate)

Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.Formal Name: N-cyclohexyl-4-(1H-imidazol-5-yl)-1-piperidinecarbothioamide, 2Z-butenedioate. CAS Number: 148440-81-7. Molecular Formula: C15H24N4S . C4H4O4. Formula Weight: 408.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 249 nm. SMILES: S=C(NC1CCCCC1)N(CC2)CCC2C3=CN=CN3.O=C(/C=C\C(O)=O)O. InChi Code: InChI=1S/C15H24N4S.C4H4O4/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14,5-3(6)1-2-4(7)8/h10-13H,1-9H2,(H,16,17)(H,18,20),1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: WUYMIKDBRCCYGE-BTJKTKAUSA-N.