Tetrahydromagnolol

Tetrahydromagnolol is an agonist of cannabinoid (CB) receptors, an antagonist of GPR55 (KB = 13.3 µM in a beta-arrestin translocation assay), and a major metabolite of magnolol (Cay-14233). Tetrahydromagnolol binds to the CB1 and CB2 receptors (Kis = 2.26 and 0.416 µM, respectively, for the human receptor) and inhibits forskolin-induced cAMP accumulation (EC50 = 9.01 and 0.17 µM, respectively, in CHO cells expressing the human receptors). Tetrahydromagnolol reduces melanin biosynthesis, as well as decreases tyrosinase protein levels by inhibiting tyrosinase maturation and increasing the rate of its degradation.Formal Name: 5,5'-dipropyl-[1,1'-biphenyl]-2,2'-diol. CAS Number: 20601-85-8. Synonyms: Magnolignan. Molecular Formula: C18H22O2. Formula Weight: 270.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 16 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 212, 292 nm. SMILES: OC(C=CC(CCC)=C1)=C1C2=CC(CCC)=CC=C2O. InChi Code: InChI=1S/C18H22O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h7-12,19-20H,3-6H2,1-2H3. InChi Key: OYAQUBKYAKSHOA-UHFFFAOYSA-N.