(±)-Talinolol

(±)-Talinolol is a beta1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking beta1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein.Formal Name: N-cyclohexyl-N'-[4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-urea. CAS Number: 57460-41-0. Molecular Formula: C20H33N3O3. Formula Weight: 363.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:20): 0.05 mg/ml, DMSO: 15 mg/ml, Ethanol: 10 mg/ml. lambdamax: 203, 245, 292 nm. SMILES: O=C(NC1CCCCC1)NC2=CC=C(OCC(O)CNC(C)(C)C)C=C2. InChi Code: InChI=1S/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25). InChi Key: MXFWWQICDIZSOA-UHFFFAOYSA-N.