6 products were found matching "Cay15750"!

Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-alpha, IL-6,...

Metamizole is a nonopioid prodrug that is rapidly hydrolyzed to the analgesic and antipyretic metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA). It inhibits COX-1 and COX-2 activity (IC50 = ~150 µg/ml for both in cell-free assays), as well as reduces increases in intracellular calcium levels...

Bufalin is a cardiotonic steroid first isolated from toad venom and used in traditional Asian medicine. It inhibits the Na+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the alpha1, alpha2, and alpha3 subunits, respectively). Intravenously administered bufalin is cleared rapidly, with a plasma half-life of 25...

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM). This compound binds to a site at the external pore of...

Carmustine is a DNA alkylating agent. It inhibits cell growth and induces cell cycle arrest at the G2/M phase in C6 rat glioma cells when used at a concentration of 10 µM. In vivo, carmustine (0.3 and 6.7 mg/kg per day) reduces tumor growth in a C6 rat glioma model. Carmustine (0.5 mg/kg, i.p.) also reduces the...

Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors). It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled...