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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40B-0003-C010 | 10 µg | - |
3 - 9 business days* |
83.00€
|
|||
AG-40B-0003-5010 | 50 µg (5 x 10 µg) | - |
3 - 9 business days* |
248.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The extracellular domain of human TRAIL (amino acids 95-281) is fused at the N-terminus to a... more
Product information "TRAIL, Soluble (human) (rec.)"
The extracellular domain of human TRAIL (amino acids 95-281) is fused at the N-terminus to a FLAG(R)-tag. Induces apoptosis of human Jurkat T cells in a concentration range of 5-50ng/ml in the presence of TNF Ligands Enhancer (Prod. No. AG-35B-0001). In the absence of TNF Ligands Enhancer, TRAIL, Soluble (human) (recombinant) is poorly active. Lyophilized. Contains PBS. TNF-related apoptosis-inducing ligand (TRAIL, Apo2L,CD253, TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to fi ve distinct receptors: TRAIL-R1 (DR4, Apo2,CD261, TNFRSF10A), TRAIL-R2 (DR5, KILLER, TRICK2A,TRICK2B, CD262, TNFRSF10B), TRAIL-R3 (DcR1,LIT, TRID, CD263, TNFRSF10C), TRAIL-R4 (DcR2,TRUNDD, CD264, TNFRSF10D), and osteoprotegerin (OPG, OCIF, TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducingthe formation of the so-called multiprotein death-inducing signaling complex (DISC).
Keywords: | APO2L, CD253, Apo-2L, TNFSF10, Apo-2 ligand, Protein TRAIL, TNF-related apoptosis-inducing ligand, Tumor necrosis factor ligand superfamily member 10 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40B-0003 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 23 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K04721 | Matching products |
UniProt ID : | P50591 | Matching products |
Gene ID | GeneID 8743 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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