Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein (Cay-10005166) and equol (Cay-13184), resulting in antithrombotic, antiallergic, and other salutary effects. When...

beta-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro. beta-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect...

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates...

Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-alpha (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial...