Defining the mechanisms responsible for alterations in cell cycle progression is crucial to understanding many human diseases, most notably cancer. Cell proliferation assays have been widely used to assess cell cycle regulatory factors such as growth factors, cytokines, mitogens, and drugs. Cayman's XTT cell...

Origin: Plant/Armoracia rusticana.

Four G protein-coupled receptors, EP1-4, initiate cellular signaling in response to prostaglandin PGE2. The receptor EP1 acts via Galphaq to evoke diverse effects, including renal vasoconstriction, bronchoconstriction, hyperalgesia, allodynia, gastric protection, hyperthermia, and sleep inhibition. GW 848687X is a...

Immunogen: purified eggshell proteins (Zrp and small amounts of zona pellucida proteins) from Atlantic salmon (S. salar). Clone Designation: MN-2B4. Formulation: (Request formulation change), Affinity-purified IgG in 0.1 M sodium phosphate, pH 7.4, containing 0.15 M sodium chloride, 1% BSA, and 12.3 mM sodium azide....

AICAR is an activator of AMP-activated protein kinase (AMPK). It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 µM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and...