9 products were found matching "Cay10004110"!

PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 µM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 µM, respectively). PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4...

PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress. It is found as a component in mildly oxidized LDL (MM-LDL) and in products formed from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC). PGPC activates peroxisome proliferator-activated receptor...

CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARgamma ligand activity and resistance to metabolism. 15-deoxy-Delta12,14-PGJ2 has been shown to be a potent ligand for PPARgamma. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and...

Isolated neonatal rat cardiomyocytes, which spontaneously beat in culture, are used to evaluate the antiarrhythmic effects of polyunsaturated fatty acids (PUFA). In this model, the omega-3 PUFA eicosapentaenoic acid (EPA, 3-10 µM) reduces the contraction rate of cells, indicating a positive antiarrhythmic effect....

Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves. Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM. Luteolin has also been found to inhibit the release of TNFalpha from neutrophils, and to inhibit...

Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is...

NESS 0327 is an extremely potent cannabinoid (CB) receptor antagonist with high selectivity for the CB1 receptor compared to the CB2 receptor with Ki values of 0.35 pM and 21 nM, respectively. It is a much more potent antagonist and more selective for the CB1 receptor compared to SR 141716A (rimonabant). At nM...

Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity. When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth is enhanced. 3,4',5-Trismethoxybenzophenone is an analog of trismethoxy resveratrol. It...

Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation. This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 µM) with weak or no effect on normal cell lines...