TNFSF11 (RANKL) (RANKL), mouse recombinant (rmoTNFSF11)

TNFSF11 (RANKL) (RANKL), mouse recombinant (rmoTNFSF11)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
RP0437M-005 5 µg -

3 - 8 business days*

206.00€
RP0437M-025 25 µg - -

3 - 8 business days*

412.00€
RP0437M-100 100 µg - -

3 - 8 business days*

1,235.00€
RP0437M-500 500 µg -

3 - 8 business days*

4,528.00€
 
Produced in Yeast. Amino acid sequence: FSGAPAMMEG SWLDVAQRGK PEAQPFAHLT INAASIPSGS HKVTLSSWYH... more
Product information "TNFSF11 (RANKL) (RANKL), mouse recombinant (rmoTNFSF11)"
Produced in Yeast. Amino acid sequence: FSGAPAMMEG SWLDVAQRGK PEAQPFAHLT INAASIPSGS HKVTLSSWYH DRGWAKISNM TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPTDYLQLM VYVVKTSIKI PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SIQVSNPSLL DPDQDATYFG AFKVQDID (178). Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts (PubMed:24039232). During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171, PubMed:26644563). [The UniProt Consortium]
Keywords: Opgl, Tnfsf11
Supplier: Kingfisher Biotech
Supplier-Nr: RP0437M

Properties

Application: Bioassays
Conjugate: No
Host: Yeast
Species reactivity: mouse
MW: 19,8 kD
Purity: >95%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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