TNF-alpha (human) (multimeric) (rec.)

The extracellular domain of human TNF-alpha (amino acids 85-233) is fused at the N-terminus to human ACRP30headless (amino acids 16-108) and a FLAG(R)-tag. Activates human and mouse TNF-R1 and TNF-R2. Lyophilized. Contains PBS. Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MegaTNF-alpha(TM) is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30.