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TNF Ligand Superfamily Member 12 (TWEAK), FLAG Tag, human recombinant, (rHuTNFSF12-HEK-FLAG)
Product information "TNF Ligand Superfamily Member 12 (TWEAK), FLAG Tag, human recombinant, (rHuTNFSF12-HEK-FLAG)"
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. (www.uniprot.org) Human recombinant TWEAK is manufactured with N-terminal fusion of 13 amino acid FLAG Tag. The TNFSF12 flag -tagged fusion protein is an 18.7kDa protein containing 169 amino acid residues and 13 additional amino acid residues - flag tag. TNFSF12 is a cytokine that is part of the TNF ligand family. TNFSF12 is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12 induces apoptosis through multiple pathways of cell death in a cell type-specific manner. TNFSF12 promotes proliferation and migration of endothelial cells, and therefore acts as a regulator of angiogenesis. TNFSF12 is expressed in adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK h induces NFkB and chemokine secretion. TNFSF12 promotes proliferation and migration of endothelial cells.
Keywords:
TWEAK, TNF-related weak inducer of apoptosis, TNFSF12, DR3LG, Apo3-Ligand, APO3L, TNFRSF12A, Tumor necrosis factor ligand superfamily member 12, MGC20669, MGC129581
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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