- Search results for Cay14494
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3 products were found matching "Cay14494"!
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Item number: Cay11494-1
Ponatinib is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor (IC50 = 0.37 nM). It inhibits the tyrosine kinase inhibitor-resistant mutant Bcr-AblT315I (IC50 = 2 nM), as well as Bcr-AblQ252H, Bcr-AblY253F, Bcr-AblM351T, and Bcr-AblH396P mutants (IC50s = 0.44, 0.3, 0.3, and 0.34 nM, respectively). It is...
Keywords: | AP 24534,... |
Application: | Bcr-Abl tyrosine kinase inhibitor |
CAS | 943319-70-8 |
MW: | 532.6 D |
From 39.00€
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Item number: Cay14994-1
Metyrapone is an inhibitor of the cytochrome P450 (CYP) enzyme 11beta-hydroxylase (IC50 = 7.83 µM), an enzyme involved in the final step of cortisol biosynthesis. It also induces Cyp1a1 and Cyp3a4 expression in rat hepatic microsomes and inhibits the activity of 11beta-hydroxysteroid dehydrogenase type 1...
Keywords: | NSC 25265, SU 4885, 2-methyl-1,2-di-3-pyridinyl-1-propanone |
Application: | 11beta-hydroxylase inhibitor, CYP450 inhibitor |
CAS | 54-36-4 |
MW: | 226.3 D |
From 34.00€
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Item number: Cay14944-250
HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol. HMGR is controlled by feedback regulation from...
Keywords: | HMG-CoA reductase, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme... |
Application: | Enzyme activity |
Origin: | human |
MW: | 76.5 kD |
409.00€
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