2 products were found matching "Cay11922-25"!

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Item number: Cay19922-25

Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5 agonist. It induces GTPgammaS binding in cell membranes expressing human S1P1 or S1P5 (EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2 or S1P3 receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number...

Keywords:	5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-benzonitrile
Application:	S1PR1 / S1PR5 modulator, Immunomodulator
CAS	1306760-87-1
MW:	404.5 D

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CCT007093

Item number: Cay19992-25

CCT007093 is an inhibitor of protein phosphatase 1D (PPM1D, also known as PP2Cdelta and WIP1, IC50 = 8.4 µM), which is encoded by a putative oncogene that is amplified in multiple cancer types. It does not inhibit PPM1A. CCT007093 selectively inhibits the growth of cancer cells that overexpress PPM1D, including...

Keywords:	2E,5E-bis(2-thienylmethylene)-cyclopentanone
Application:	PPM1D inhibitor
CAS	176957-55-4
MW:	272.4 D

From 43.00€ *

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