4 products were found matching "Cay11922"!
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Ozanimod
Item number: Cay19922-5
Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5 agonist. It induces GTPgammaS binding in cell membranes expressing human S1P1 or S1P5 (EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2 or S1P3 receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number...
| Keywords: | 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-benzonitrile |
| Application: | S1PR1 / S1PR5 modulator, Immunomodulator |
| CAS | 1306760-87-1 |
| MW: | 404.5 D |
From 60.00€
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AM2201 6-hydroxyindole metabolite
Item number: Cay11192-5
AM2201 is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central CB1 and peripheral CB2 receptors, respectively. AM2201 6-hydroxyindole metabolite is an expected metabolite of AM2201 generated during phase I metabolism by cytochrome P450, suggesting that it would be detectable in blood...
| Keywords: | (1-(5-fluoropentyl)-6-hydroxy-1H-indol-3-yl)(naphthalen-1-yl)methanone |
| Application: | Analytical reference standard, Expected AM2201 metabolite |
| CAS | 1427521-35-4 |
| MW: | 375.4 D |
From 339.00€
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CCT007093
Item number: Cay19992-1
CCT007093 is an inhibitor of protein phosphatase 1D (PPM1D, also known as PP2Cdelta and WIP1, IC50 = 8.4 µM), which is encoded by a putative oncogene that is amplified in multiple cancer types. It does not inhibit PPM1A. CCT007093 selectively inhibits the growth of cancer cells that overexpress PPM1D, including...
| Keywords: | 2E,5E-bis(2-thienylmethylene)-cyclopentanone |
| Application: | PPM1D inhibitor |
| CAS | 176957-55-4 |
| MW: | 272.4 D |
From 43.00€
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Ro 67-4853
Item number: Cay11992-5
Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1), enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16). While only mildly potentiating mGluR5 signaling, this compound is without effect at mGluR2, mGluR4, or mGluR8,...
| Keywords: | N-(9H-xanthen-9-ylcarbonyl)-carbamic acid, butyl ester |
| Application: | mGluR1 modulator |
| CAS | 302841-89-0 |
| MW: | 325.4 D |
From 43.00€
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