SuperKillerTRAIL(TM), Soluble (human, rec.)

SuperKillerTRAIL(TM), Soluble (human, rec.)
%
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
AG-40T-0002-C020 20 µg -

3 - 9 business days*

10 %
374.00€
336.60€
AG-40T-0002-3020 60 µg (3 x 20 µg) -

3 - 9 business days*

10 %
759.00€
683.10€
 
(3 x 20µg). The extracellular domain of human TRAIL (amino acids 95-281) is fused at the... more
Product information "SuperKillerTRAIL(TM), Soluble (human, rec.)"
(3 x 20µg). The extracellular domain of human TRAIL (amino acids 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge. Induces apoptosis at concentrations of >1ng/ml. Note: Does not require a cross-linking enhancer for its potent biological activity. Shows superior activity on human cell lines that require extensive cross-linking of TRAIL-Rs for killing (e.g. Jurkat). Liquid. In 20mM HEPES, pH 7.9, 120mM NaCl, 0.01% Tween 20, 1% sucrose, 1mM DTT. TNF-related apoptosis-inducing ligand (TRAIL, Apo2L,CD253, TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4, Apo2,CD261, TNFRSF10A), TRAIL-R2 (DR5, KILLER, TRICK2A,TRICK2B, CD262, TNFRSF10B), TRAIL-R3 (DcR1,LIT, TRID, CD263, TNFRSF10C), TRAIL-R4 (DcR2, TRUNDD, CD264, TNFRSF10D), and osteoprotegerin (OPG, OCIF, TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC).
Keywords: TRAIL, Apo-2L, TNFSF10, CD253
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-40T-0002

Properties

Application: Bioassays
Conjugate: No
Host: E.coli
Species reactivity: human
Format: Liquid

Database Information

KEGG ID : K04721 | Matching products
UniProt ID : P50591 | Matching products

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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