Stromal Cell-Derived Factor-1 beta (CXCL12), human recombinant (rHuSDF-1b)

Stromal Cell-Derived Factor-1 beta (CXCL12), human recombinant (rHuSDF-1b)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
94863.2 2 µg - -

3 - 10 business days*

94.00€
94863.10 10 µg - -

3 - 10 business days*

208.00€
94863.1 1 mg - -

3 - 10 business days*

3,952.00€
 
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C... more
Product information "Stromal Cell-Derived Factor-1 beta (CXCL12), human recombinant (rHuSDF-1b)"
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase. (www.uniprot.org) Produced in E.coli as a non-glycosylated, polypeptide chain containing 72 amino acids. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development.
Keywords: SDF-1, CXCL12, Pre-B cell growth-stimulating factor, PBSF, hIRH, chemokine (C-X-C motif) ligand 12, SDF1, SDF1B, TPAR1, SCYB12, SDF-1b, TLSF-b
Supplier: Biomol GmbH
Supplier-Nr: 94863

Properties

Application: Chemoattract.
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 8508.00 D
Format: Lyophilized

Database Information

KEGG ID : K10031 | Matching products
UniProt ID : P48061 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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