Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
S6500-06F.10 | 10 µg | - | - |
3 - 19 business days* |
985.00€
|
Src is a member of the Src family of protein tyrosine kinases. This kinase is expressed in... more
Product information "Src, Recombinant, Human (pp60Src, pp60c-Src)"
Src is a member of the Src family of protein tyrosine kinases. This kinase is expressed in different tissues of the body with the highest protein levels detected in neurons and platelets. Src can modulate the signal transduction pathways activated by several growth factors (e.g., PDGF, M-CSF and G-CSF) and integrins. Src also regulates the activity of several ion channels including the N-methyl-D-aspartate (NMDA) receptor. In addition, Src is thought to play a role in physiological/pathophysiological processes in the central nervous system. It has also been reported that mice deficient in Src develop severe osteoporosis. A total of eight membrane-associated protein tyrosine kinases have been identified within the Src gene family. Members of this group include c-Src, c-Yes, Fyn, Lck, Lyn, Blk and c-Fgr whose roles include regulation of cytoskeletal organization, cell-cell contact, DNA synthesis, proliferation and differentiation of eukaryotic cells. Elevated activity of the proto-oncogene Src has been found in many human cancers, most notably breast cancer.The highest levels of expression of the prototype member of this gene family, Src p60, are observed in platelets and in neuronal tissues. With the fact that platelets have constitutively high levels of phosphotyrosine-containing proteins suggest that Src p60 may be important for platelet homeostasis. , Description:, Full-length recombinant human SRC (GenBank Accession #NM_005417) with N-terminal His tag, expressed in a Baculovirus-infected Sf9 cell expression system. Molecular Weight: 61kD, Specific Activity (pmol/min/ug): As reported (lot-specific), Assay Conditions: Kinase buffer containing 1mM DTT using Poly-(Glu4:Tyr) substrate (0.2mg/ml) and 20mM ATP, incubation time: 35 minutes at room temperature. Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Avoid freeze-thaw cycles. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
Keywords: | SRC1, p60-Src, pp60c-src, EC=2.7.10.2, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src |
Supplier: | United States Biological |
Supplier-Nr: | S6500-06F |
Properties
Conjugate: | No |
MW: | 60.5 kD |
Purity: | 80% |
Format: | Purified |
Database Information
KEGG ID : | K05704 | Matching products |
UniProt ID : | P12931 | Matching products |
Gene ID | GeneID 6714 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed