Sphingosine Kinase Inhibitor 2

Sphingosine Kinase Inhibitor 2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009222-5 5 mg -

6 - 10 business days*

54.00€
Cay10009222-10 10 mg -

6 - 10 business days*

102.00€
Cay10009222-25 25 mg -

6 - 10 business days*

237.00€
Cay10009222-50 50 mg -

6 - 10 business days*

418.00€
 
Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to... more
Product information "Sphingosine Kinase Inhibitor 2"
Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Sphingosine kinase inhibitor 2 is an inhibitor of sphingosine kinase 1 (SPHK1) with an IC50 value of 0.5 µM for non-ATP-competitive inhibition of human recombinant SPHK1. It is selective for SPHK1 over ERK2, PI3K, and PKCalpha at concentrations up to 60 µM. Sphingosine kinase inhibitor 2 inhibits proliferation of several cancer cell lines, including T-24, MCF-7, NCI/ADR, and MCF-7/VP (IC50s = 0.9-4.6 µM).Formal Name: 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol. CAS Number: 312636-16-1. Synonyms: SKI II, SPHK I2. Molecular Formula: C15H11ClN2OS. Formula Weight: 302.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 259, 282 nm. SMILES: OC1=CC=C(N([H])C2=NC(C3=CC=C(Cl)C=C3)=CS2)C=C1. InChi Code: InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18). InChi Key: ZFGXZJKLOFCECI-UHFFFAOYSA-N.
Keywords: SKI II, SPHK I2, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol
Supplier: Cayman Chemical
Supplier-Nr: 10009222

Properties

Application: SPHK1 inhibitor
MW: 302.8 D
Formula: C15H11ClN2OS
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 312636-16-1| Matching products
KEGG ID : K04718 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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