Sotalol (hydrochloride)

Sotalol (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16136-10 10 mg -

6 - 10 business days*

43.00€
Cay16136-25 25 mg -

6 - 10 business days*

76.00€
Cay16136-50 50 mg -

6 - 10 business days*

105.00€
Cay16136-100 100 mg -

6 - 10 business days*

161.00€
 
Sotalol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs, IC50s = 8.9 and 5.2... more
Product information "Sotalol (hydrochloride)"
Sotalol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs, IC50s = 8.9 and 5.2 µM for beta1- and beta2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 µM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).Formal Name: N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-methanesulfonamide, monohydrochloride. CAS Number: 959-24-0. Synonyms: MJ1999, (±)-Sotalol, DL-Sotalol. Molecular Formula: C12H20N2O3S . HCl. Formula Weight: 308.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 230 nm. SMILES: CS(NC1=CC=C(C(O)CNC(C)C)C=C1)(=O)=O.Cl. InChi Code: InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17,/h4-7,9,12-15H,8H2,1-3H3,1H. InChi Key: VIDRYROWYFWGSY-UHFFFAOYSA-N.
Keywords: (±)-Sotalol, DL-Sotalol, MJ1999, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-methanesulfonamide, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 16136

Properties

Application: beta1/2-adrenergic receptor antagonist
MW: 308.8 D
Formula: C12H20N2O3S . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 959-24-0| Matching products
KEGG ID : K04141 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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