17 products were found matching "SYN-1082-M100"!

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TASP0415914
TASP0415914

Item number: SYN-1208-M100

Soluble in DMSO. PI3Kgamma is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-inflammatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in...
Keywords: TASP-0415914
Application: PI3K gamma inhibitor
CAS 1292300-75-4
MW: 323,4 D
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CC-401 hydrochloride
CC-401 hydrochloride

Item number: SYN-1028-M100

Soluble in DMSO. CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least...
Keywords: CC401
Application: JNK inhibitor
CAS 1438391-30-0
MW: 424,9 D
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CX-6258
CX-6258

Item number: SYN-1182-M001

Soluble in DMSO. CX6258 is a potent inhibitor of Pim-1, Pim-2 and Pim-3 with IC(50) values of 5, 25 and 16nM, respectively. Target: PKC - PKC alpha, , Kinase Group: STE , Substrate: Serine-Threonine
Keywords: CX6258
Application: Pim-1 / Pim-2 / Pim-3 inhibitor
CAS 1202916-90-2
MW: 461,9 D
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Lapatinib
Lapatinib

Item number: SYN-1052-M100

Soluble in DMSO or ethanol. Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor, with IC(50) values of 10.8 and 9.2nM respectively. It is an orally active drug for treatment of breast cancer and other solid tumors. Target: EGFR , Kinase...
Keywords: GW-572016
Application: EGFR / ErbB2 inhibitor
CAS 231277-92-2
MW: 581,1 D
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Linifanib
Linifanib

Item number: SYN-1002-M100

Soluble in DMSO or ethanol. Linifanib (A 741439, A-741439, A741439, ABT-869, ABT869, RG3635) is an orally active multi-targeted receptor tyrosine kinase inhibitor for the treatment of various cancers. The compound is designed to inhibit vascular endothelial growth factor and platelet-derived growth factor receptors...
Keywords: ABT-869, AL39324, RG-3635
Application: PDGFR / VEFGR inhibitor
CAS 796967-16-3
MW: 375,4 D
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AV-412
AV-412

Item number: SYN-1012-M100

Soluble in DMSO or ethanol. AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the...
Keywords: MP-412, AV412
Application: EGFR / ErbB2 inhibitor
CAS 451492-95-8
MW: 507 D
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Gefitinib
Gefitinib

Item number: SYN-1042-M100

Soluble in DMSO or ethanol. Gefitinib is a selective, orally available epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. In NR6wtEGFR and NR6W cells, it inhibits Tyr1173, Tyr992, Tyr1173 and Tyr992 with IC(50) values of 37nM, 37nM, 26nM and 57nM, respectively. Target: EGFR , Kinase Group: RTK ,...
Keywords: ZD1839, Iressa
Application: EGFR inhibitor
CAS 184475-35-2
MW: 446,9 D
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PD-173955-Analog1
PD-173955-Analog1

Item number: SYN-1062-M100

Soluble in DMSO or ethanol. Slightly soluble (<1mg/ml) in water. PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively. Substrate: Tyrosine
Keywords: PD173955-Analog1, PD-173,955-Analog1
Application: c-Src / CSK inhibitor
CAS 185039-99-0
MW: 441,3 D
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BMS-387032
BMS-387032

Item number: SYN-1080-M100

Soluble in DMSO or ethanol. BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It...
Keywords: BMS387032, SNS-032
Application: CDK2 / CDK9 inhibitor
CAS 345627-90-9
MW: 417,0 D
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SNS-314
SNS-314

Item number: SYN-1081-M100

Soluble in DMSO or ethanol. Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes,...
Keywords: SNS314
Application: Aurora inhibitor
CAS 1057249-41-8
MW: 430,9 D
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RWJ-67657
RWJ-67657

Item number: SYN-1072-M100

Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...
Keywords: RWJ67657
Application: p38 inhibitor
CAS 215303-72-3
MW: 425,5 D
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SR3677
SR3677

Item number: SYN-1083-M100

Soluble in DMSO. SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow...
Keywords: SR-3677
Application: ROCK2 inhibitor
CAS 1072959-67-1
MW: 408,5 D
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