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Item number: Cay16713-5

Semagacestat is a potent inhibitor of gamma-secretase that blocks the production of Abeta38, Abeta40, and Abeta42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates gamma-secretase activity in vivo, altering Abeta levels in brain,...

Keywords:	LY450139,...
Application:	gamma-secretase inhibitor
CAS	425386-60-3
MW:	361.4 D

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