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SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka... more
Product information "SU 1498"
SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1, IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases. It effectively blocks signaling through VEGFR2 both in vitro and in vivo. SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.Formal Name: (2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide. CAS Number: 168835-82-3. Synonyms: AG-1498, Tyrphostin SU 1498. Molecular Formula: C25H30N2O2. Formula Weight: 390.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 249, 348, 356 nm. SMILES: O=C(/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1)NCCCC2=CC=CC=C2. InChi Code: InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+. InChi Key: JANPYFTYAGTSIN-FYJGNVAPSA-N.
Keywords: | AG-1498, Tyrphostin SU 1498, (2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 16354 |
Properties
Application: | VEGFR2 inhibitor |
MW: | 390.5 D |
Formula: | C25H30N2O2 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 168835-82-3| Matching products |
KEGG ID : | K05098 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302, H312, H315, H319, H332, H335 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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