5 products were found matching "Cay19025-1"!
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Thromboxane B3
Item number: Cay19990-25
Thromboxane B3 (TXB3) is the stable hydrolysis product of TXA3 synthesized from eicosapentaenoic acid (EPA, Cay-90110) by COX and thromboxane synthase. It is biosynthesized in various tissues such as seminal vesicles, lung, PMNL, and ocular tissues.Formal Name: 9alpha,11,15S-trihydroxy-thromba-5Z,13E,17Z-trien-1-oic...
| Keywords: | TXB3, Delta17-TXB2, 9alpha,11,15S-trihydroxy-thromba-5Z,13E,17Z-trien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 71953-80-5 |
| MW: | 368.5 D |
From 158.00€
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Prostaglandin B3
Item number: Cay11990-25
Prostaglandin B3 (PGB3) is a non-enzymatic dehydration product resulting from the treatment of Prostaglandin E3 (PGE3) with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARgamma, PGB3 exhibited a Ki value greater than 1 mM. In contrast, PGB1 and...
| Keywords: | PGB3, 9-oxo-15S-hydroxy-prosta-5Z,8(12),13E,17Z-tetraen-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 36614-32-1 |
| MW: | 332.4 D |
From 130.00€
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A-769662
Item number: Cay11900-25
A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates beta1 subunit-containing AMPK heterotrimers, and its effects are independent...
| Keywords: | 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Application: | AMPK activator |
| CAS | 844499-71-4 |
| MW: | 360.4 D |
From 88.00€
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ON-123300
Item number: Cay19902-5
ON-123300 is a multi-kinase inhibitor. It inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively) as well as FYN, PDGFRbeta, Abl, and PI3Kdelta (IC50s = 11.09, 26, 53.32, and 144 nM, respectively) among others. It inhibits proliferation in a panel of 38 cancer cell lines (GI50s = 0.05-5 µM)....
| Keywords: | 8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile |
| Application: | CDK inhibitor |
| CAS | 1357470-29-1 |
| MW: | 429.5 D |
From 50.00€
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I-SAP
Item number: Cay19021-1
I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and...
| Keywords: | Iodophenyl sulfonyl amino pinane Thromboxane A2, Iodophenyl sulfonyl amino pinane TXA2,... |
| Application: | TP receptor antagonist |
| CAS | 133538-58-6 |
| MW: | 531.4 D |
From 98.00€
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