8 products were found matching "Cay14136-25"!

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Glycitein
Glycitein

Item number: Cay14162-5

Glycitein is an O-methylated isoflavone that comprises 5-10% of the total isoflavones in soy food products. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro with an IC50 value of 3.94 µM. It suppresses the proliferation of osteoblasts and...
Keywords: 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Application: Metabolic studies
CAS 40957-83-3
MW: 284.3 D
From 66.00€ *
Review
SMN tudor domain (human recombinant)
SMN tudor domain (human recombinant)

Item number: Cay14136-100

Tudor domains are small protein structural motifs of ~50 amino acids related to the "Royal family" of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism,...
Keywords: SMN, SMN1, SMN2, SMNC, Gemin-1, Gemin-1, Component of gems 1, Component of gems 1, Survival motor neuron protein, Survival...
Application: Binding assays
Expressed in: E.coli
Origin: human
MW: 42,6 kD
465.00€ *
Review
(S)-10-hydroxy-Camptothecin
(S)-10-hydroxy-Camptothecin

Item number: Cay14635-25

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of...
Keywords: ChEMBL 273862, NSC 107124, (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Application: Topoisomerase I inhibitor
CAS 19685-09-7
MW: 364.4 D
From 77.00€ *
Review
Cycloheximide
Cycloheximide

Item number: Cay14126-1

Cycloheximide is a glutarimide antibiotic produced by S. griseus that inhibits protein synthesis in eukaryotes (IC50 = 5-50 µM) by interfering with translational elongation. Its effects on protein synthesis can either induce or inhibit apoptosis depending on cell type. Cycloheximide is widely used as a tool in...
Keywords: Naramycin A, NSC 185, 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione
Application: Protein synthesis inhibitor
CAS 66-81-9
MW: 281.4 D
From 40.00€ *
Review
Clofarabine
Clofarabine

Item number: Cay14125-5

Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-alpha (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial...
Keywords: Clolar, Evoltra, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
Application: Ribonucleotide reductase and DNA polymerase-alpha Inhibitor
CAS 123318-82-1
MW: 303.7 D
From 52.00€ *
Review
Temozolomide
Temozolomide

Item number: Cay14163-25

Temozolomide is a prodrug form of the DNA alkylating agent MTIC (Cay-18863). It is converted to MTIC in a non-enzymatic manner under physiological conditions. Temozolomide is selectively cytotoxic to U87 and D54 glioblastoma cells, which do not express O6-methylguanine-DNA methyltransferase (MGMT), over...
Keywords: CCRG 81045, MB 39831, Methazolastone, NSC 362856, Temodal, TMZ,...
Application: DNA alkylating agent, apoptosis inducer
CAS 85622-93-1
MW: 194.2 D
From 66.00€ *
Review
(1'S,2'S)-Nicotine-1'-oxide
(1'S,2'S)-Nicotine-1'-oxide

Item number: Cay16413-25

(1'S,2'S)-Nicotine-1'-oxide is a stereoisomer of the naturally occurring nicotine metabolite, nicotine-1'-N-oxide. Nicotine-1'-N-oxide is a potential intermediate in the N-demethylation of nicotine.Formal Name: 3-[(1S,2S)-1-methyl-1-oxido-2-pyrrolidinyl]-pyridine. CAS Number: 51095-86-4. Synonyms:...
Keywords: Nicotine-cis-N-oxide, 3-[(1S,2S)-1-methyl-1-oxido-2-pyrrolidinyl]-pyridine
CAS 51095-86-4
MW: 178.2 D
From 125.00€ *
Review
Anti-Irisin
Anti-Irisin

Item number: Cay14625-1

Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1alpha (PGC-1alpha), regulates mitochondrial biogenesis and function. Expression of the membrane protein fibronectin...
Keywords: Anti-FNDC5, Anti-FRCP2, Anti-Irisin, Anti-Fibronectin type III domain-containing protein 5, Anti-Fibronectin type III...
Application: ELISA, WB
Host: Rabbit
564.00€ *
Review