SLF

SLF
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10007974-5 5 mg -

6 - 10 business days*

123.00€
Cay10007974-10 10 mg -

6 - 10 business days*

233.00€
Cay10007974-50 50 mg -

6 - 10 business days*

963.00€
Cay10007974-100 100 mg -

6 - 10 business days*

1,612.00€
 
FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506... more
Product information "SLF"
FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation. Synthetic ligand of FKBP (SLF) is a cell-permeable analog of FK-506 that binds tightly to FKBP but lacks the ability to inhibit calcineurin. By itself, SLF does not exhibit a significant cellular response. However, homodimers of SLF or heterodimers with another protein ligand, provide a method to promote the dimerization of ligand-specific fusion proteins to induce signaling events within a cellular environment. For example, SLF monomers connected with a 10-atom linker activates Fas signaling via Fas-FKBP fusion proteins with an EC50 of 6 nM.Formal Name: 1-(3,3-dimethyl-1,2-dioxopentyl)-(2S)-2-piperidinecarboxylic acid, (1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester. CAS Number: 195513-96-3. Synonyms: Synthetic Ligand of FKBP. Molecular Formula: C30H40N2O6. Formula Weight: 524.7. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2)(1:3): .2 mg/ml. lambdamax: 205, 232, 281 nm. SMILES: COc1cc(CCC(OC(=O)[C@@H]2CCCCN2C(=O)C(=O)C(C)(C)CC)c2cccc(N)c2)ccc1OC. InChi Code: InChI=1S/C30H40N2O6/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1. InChi Key: IIDSDBBDZNDWCN-BJKOFHAPSA-N.
Keywords: Synthetic Ligand of FKBP, 1-(3,3-dimethyl-1,2-dioxopentyl)-(2S)-2-piperidinecarboxylic acid, (1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester
Supplier: Cayman Chemical
Supplier-Nr: 10007974

Properties

Application: FK-506 analog
MW: 524.7 D
Formula: C30H40N2O6
Purity: >98%
Format: Solution

Database Information

CAS : 195513-96-3| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319
P Phrases: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P305+351+338, P337+313, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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