- Search results for Cay15598
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4 products were found matching "Cay15598"!
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Item number: Cay15598-5
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 µM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much...
Keywords: | alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-benzeneacetonitrile |
Application: | MEK1 / MEK2 inhibitor |
CAS | 305350-87-2 |
MW: | 335.4 D |
From 77.00€
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Item number: Cay11598-5
Tofacitinib is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively). It is selective for JAK1-3 over ROCK2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits...
Keywords: | Tofacitinib citrate,... |
Application: | JAK inhibitor |
CAS | 540737-29-9 |
MW: | 504.5 D |
From 92.00€
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Item number: Cay15988-100
7-Methylguanosine is a methylated form of the purine nucleoside guanosine (Cay-27702). It is an RNA modification that is present in the 5'-terminal cap of mRNA, where it promotes translation, as well as in tRNA, where it stabilizes the tRNA structure. 7-Methylguanosine has been used as a substrate to measure the...
Keywords: | 7-methyl-guanosine |
Application: | 5' terminal cap structure analog, cancer biomarker |
CAS | 20244-86-4 |
MW: | 297.3 D |
From 43.00€
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Item number: Cay15998-10
In addition to intrinsic antioxidant activities, melatonin (Cay-14427) evokes its effects through the G protein-coupled receptors MT1A (MT1) and MT1B (MT2). Luzindole is a melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values are = 10-27 and 158-513 nM, respectively). Luzindole is used...
Keywords: | N-0774, N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]-acetamide |
Application: | Melatonin receptor MTNR1B antagonist |
CAS | 117946-91-5 |
MW: | 292.3 D |
From 84.00€
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