SL 0101-1

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 µM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 µM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 µM attenuating angiotensin II-induced cell proliferation.Formal Name: 3-[(3,4-di-O-acetyl-6-deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 77307-50-7. Molecular Formula: C25H24O12. Formula Weight: 516.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.33 mg/ml, DMSO: 0.16 mg/ml. SMILES: O=C(C(O[C@@H]1O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1O)=C(C2=CC=C(O)C=C2)O3)C4=C3C=C(O)C=C4O. InChi Code: InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1. InChi Key: SXOZSDJHGMAEGZ-IGKKHSBFSA-N.