12 products were found matching "Cay10316-25"!

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Treprostinil
Treprostinil

Item number: Cay10162-5

Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin (Cay-18220) that is used clinically for the treatment of PPH under the trade name Remodulin(TM). The structural...
Keywords: BW 15AU, LRX 15, Rumodolin, U-62840, Uniprost,...
Application: Prostacyclin analog, prostaglandin I2 receptor agonist
CAS 81846-19-7
MW: 390.5 D
From 130.00€ *
Review
SIRT7 (human, recombinant)
SIRT7 (human, recombinant)

Item number: Cay10316-100

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins,...
Keywords: SIR2L7, SIR2-like protein 7, SIR2-like protein 7, Regulatory protein SIR2 homolog 7, Regulatory protein SIR2 homolog 7,...
Application: WB
642.00€ *
Review
CAY10535
CAY10535

Item number: Cay10010396-25

TPalpha and TPbeta are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPbeta is believed to be responsible for vascular endothelial growth factor-induced...
Keywords: N-(tert-butylcarbamoyl)-2-(3-methoxyphenoxy)-5-nitrobenzenesulfonamide
Application: TP receptor antagonist
CAS 945716-28-9
MW: 423.4 D
From 48.00€ *
Review
Anti-Chemokine-Like Receptor 1
Anti-Chemokine-Like Receptor 1

Item number: Cay10325-1

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin, or TIG2, has been identified as the natural ligand for this receptor. Resolvin E1 has also...
Keywords: Anti-CMKLR1, Anti-CHEMR23, Anti-Chemokine-like receptor 1, Anti-Chemokine-like receptor 1, Anti-G-protein coupled receptor...
Application: FC, IF, IHC, WB
Host: Rabbit
Species reactivity: human
422.00€ *
Review
Chemokine-Like Receptor 1 Blocking Peptide
Chemokine-Like Receptor 1 Blocking Peptide

Item number: Cay10326-1

Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin (TIG2) has been identified as the natural ligand for this receptor. Resolvin E1 has also been...
Keywords: CMKLR1, DEZ, GPCR ChemR23, Resolvin E1 Receptor
Application: FC, IF, WB
177.00€ *
Review
SIRT6 (human, recombinant)
SIRT6 (human, recombinant)

Item number: Cay10315-100

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins,...
Keywords: SIRT6, SIR2L6, SIR2-like protein 6, SIR2-like protein 6, Regulatory protein SIR2 homolog 6, Regulatory protein SIR2...
Application: Enzyme kinetics, Inhibitor screening
595.00€ *
Review
Biotin-X-NHS
Biotin-X-NHS

Item number: Cay13316-250

N-Hydroxysuccinimide (NHS) activates carboxylic acid groups (on biotin) to facilitate coupling reactions. Biotin-X-NHS is a compound used to attach biotin to primary amines under alkaline conditions (pH~8-9). For example, lysines on the surface of proteins, including antibodies, are ideal targets for biotinylation...
Keywords: 6-[[5-[(3aS,4S,6aR)-hexhydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-2,5-dioxo-hexanoic acid,...
Application: Biotinylation
CAS 72040-63-2
MW: 454.5 D
From 158.00€ *
Review
StemRegenin 1
StemRegenin 1

Item number: Cay10625-10

Extending the pluripotency of hematopoietic stem cells (HSC) is of key importance to the application of stem cell therapies in a variety of diseases. Loss of the expression of the cell surface proteins CD34 and CD133 is one marker of HSC differentiation and thus often monitored in assays to test potential compounds...
Keywords: SR1, 4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol
Application: Aryl hydrocarbon receptor inhibitor
CAS 1227633-49-9
MW: 429.5 D
From 39.00€ *
Review
Indole-3-carbinol
Indole-3-carbinol

Item number: Cay11325-25

Indole-3-carbinol (I3C) is a natural phytochemical produced in crucifers by the action of myrosinase on glucobrassinin. It has been shown to have anti-cancer effects, at least in part through inhibition of NF-kappaB and Akt signaling pathways. I3C may undergo a condensation reaction in vivo, leading to the...
Keywords: 1H-Indole-3-methanol, 3-hydroxymethyl Indole, 3-Indolylmethanol, I3C, Indinol, NSC 525801, 1H-indole-3-methanol
Application: Myrosinase product, Anticancer compound
CAS 700-06-1
MW: 147.2 D
From 27.00€ *
Review
Prostaglandin A3
Prostaglandin A3

Item number: Cay10310-25

Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and...
Keywords: PGA3, 9-oxo-15S-hydroxy-prosta-5Z,10,13E,17Z-tetraen-1-oic acid
Application: Bioactive lipid assays
CAS 36614-31-0
MW: 332.4 D
From 130.00€ *
Review
8,12-iso-iPF2alpha-VI-1,5-lactone
8,12-iso-iPF2alpha-VI-1,5-lactone

Item number: Cay10312-25

F2 isoprostanes (F2-iPs) are thought to arise from the free radical-mediated peroxidation of phospholipid-bound arachidonic acid. They are cleaved, presumably by an unidentified phospholipase A2, and are found in the circulation and the urine. 8,12-iso-iPF2alpha-VI-1,5-lactone is a racemic mixture of the lactone...
Keywords: 6-((E)-2-((1R,2S,3R,5S)-3,5-dihydroxy-2-((Z)-oct-2-enyl)cyclopentyl)vinyl)tetrahydro-2H-pyran-2-one
Application: Bioactive lipid assays
MW: 336.5 D
From 156.00€ *
Review
21-desacetyl Deflazacort
21-desacetyl Deflazacort

Item number: Cay20316-5

21-desacetyl Deflazacort is the active glucocorticoid derived from the prodrug deflazacort (Cay-20386). 21-desacetyl Deflazacort and related glucocorticoids have anti-inflammatory and immunosuppressant effects, as well as benefits in certain muscular dystrophies.Formal Name:...
Keywords: L-6,485, 11beta,21-dihydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16beta-d]oxazole-3,20-dione
Application: Deflazacort metabolite
CAS 13649-57-5
MW: 399.5 D
From 34.00€ *
Review