SIRT6 (human, recombinant)

SIRT6 (human, recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10315-100 100 µg -

6 - 10 business days*

595.00€
 
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class... more
Product information "SIRT6 (human, recombinant)"
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-7. SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-kappaB signaling. Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature ageing disorder, and have a shortened life span. Since SIRT6 binds and attenuates NF-kappaB signaling, it is proposed that activators of SIRT6 may be effective anti-cancer and anti-inflammatory drugs and may increase longevity.Synonyms: NAD-dependent Deacetylase 6, Silent Information Regulator 6, SIR2L6, SIR2-like Protein 6, Sirtuin 6. Purity: >80% estimated by SDS-PAGE. Source: active recombinant N-terminal His-tagged enzyme expressed in E. coli. Amino Acids: 1-355. MW: 43.7 kDa. Formulation: (Request formulation change), 25 mM Tris-HCl, pH 8.0, with 100mM NaCl, 20% glycerol. UniProt Accession #: Q8N6T7.
Keywords: SIRT6, SIR2L6, SIR2-like protein 6, SIR2-like protein 6, Regulatory protein SIR2 homolog 6, Regulatory protein SIR2 homolog 6, NAD-dependent protein deacetylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6
Supplier: Cayman Chemical
Supplier-Nr: 10315

Properties

Application: Enzyme kinetics, Inhibitor screening
Conjugate: No
Purity: >80% estimated by SDS-PAGE
Format: Liquid

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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