9 products were found matching "Cay10317-50"!

Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and...

There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1-SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and ADP-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the...

The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4. Binding of PGE2 to the EP2 receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP. Pharmacologicially,...

Numerous analogs of fatty acyl ethanolamides potentiate the intrinsic biological activity of endocannabinoids. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. However, Ueda, et al. has recently cloned another...

Apoptosis can be induced when procaspase-3 is activated and converted to caspase-3. Procaspase-activating compound 1 (PAC-1) is a procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3. PAC-1's effectiveness was found to be directly proportional to the...

In plants, certain unsaturated fatty acids are oxygenated and then further modified along the jasmonate pathway to produce plant hormones that are involved in senescence, flower development, mechanotransduction, and the response to herbivory. dinor-12-oxo-Phytodienoic acid (dinor-OPDA) is an intermediate in the...

Protein Arginine Methyltransferases (PRMTs) are S-adenosyl-L-methionine-dependent enzymes that catalyze post-translational modification of arginine residues by methylation in three different ways: monomethylation, symmetric dimethylation, or asymmetric dimethylation at terminal arginine guanidino nitrogen atoms....

Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...

The Wittig reaction is a frequently used method for olefin synthesis involving a phosphorane ylide and an aldehyde or ketone. DPP is a common by-product of this reaction. DPP can be used as a standard in analyzing products of synthetic routes that utilize the Wittig reaction.Formal Name:...