- Search results for Cay10317-25
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15 products were found matching "Cay10317-25"!
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Item number: Cay10009317-25
Apoptosis can be induced when procaspase-3 is activated and converted to caspase-3. Procaspase-activating compound 1 (PAC-1) is a procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3. PAC-1's effectiveness was found to be directly proportional to the...
Keywords: | Procaspase-activating Compound 1, 4-(phenylmethyl)-1-piperazineacetic acid,... |
Application: | Procaspase-3 activator |
CAS | 315183-21-2 |
MW: | 392.5 D |
From 145.00€
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Item number: Cay13172-5
Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and...
Keywords: | Histone Deacetylase Inhibitor II, m-Carboxycinnamic Acid bis-Hydroxamide,... |
Application: | HDAC inhibitor |
CAS | 174664-65-4 |
MW: | 222.2 D |
From 110.00€
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Item number: Cay10317-100
There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1-SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and ADP-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the...
Keywords: | SIR2L4, SIR2-like protein 4, SIR2-like protein 4, Regulatory protein SIR2 homolog 4, Regulatory protein SIR2 homolog 4,... |
Application: | WB |
Expressed in: | E.coli |
MW: | 61,9 kD |
642.00€
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Item number: Cay10010337-25
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate |
Application: | Hydroxymethylglutaryl-coenzyme A reductase inhibitor |
MW: | 410.5 D |
From 35.00€
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Item number: Cay10010367-25
The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a...
Keywords: | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide |
Application: | Raf-1 inhibitor |
CAS | 208260-29-1 |
MW: | 389.4 D |
From 58.00€
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Item number: Cay11725-25
Platycodin D is a saponin isolated from the root of P. grandiflorum. Root preparations have been used extensively in Chinese herbal medicine for many applications, particularly for upper respiratory disorders and inflammation. The cellular and physiological actions of purified platycodin D have not been...
Keywords: | 3beta-(beta-D-glucopyranosyloxy)-2beta,16alpha,23,24-tetrahydroxy-O-D-apio-beta-D-furanosyl-(1->3)-O-beta-D-xylopyranosyl-... |
Application: | Saponin, Chinese medicinal herb isolate |
CAS | 58479-68-8 |
MW: | 1225.3 D |
From 43.00€
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Item number: Cay10325-1
Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin, or TIG2, has been identified as the natural ligand for this receptor. Resolvin E1 has also...
Keywords: | Anti-CMKLR1, Anti-CHEMR23, Anti-Chemokine-like receptor 1, Anti-Chemokine-like receptor 1, Anti-G-protein coupled receptor... |
Application: | FC, IF, IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
422.00€
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Item number: Cay31317-250
Telaprevir-d4 is intended for use as an internal standard for the quantification of telaprevir (Cay-20054) by GC- or LC-MS. Telaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural protease 3/4A (NS3/4A, Ki = 7 nM). It inhibits viral replication in genotype 1b HCV replicon cells and isolated human fetal...
Keywords: | (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-((cyclopropyl-... |
Application: | GC-MS, LC-MS, Internal standard, Quantification |
MW: | 683.9 D |
936.00€
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Item number: Cay10315-100
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins,...
Keywords: | SIRT6, SIR2L6, SIR2-like protein 6, SIR2-like protein 6, Regulatory protein SIR2 homolog 6, Regulatory protein SIR2... |
Application: | Enzyme kinetics, Inhibitor screening |
595.00€
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Item number: Cay11325-25
Indole-3-carbinol (I3C) is a natural phytochemical produced in crucifers by the action of myrosinase on glucobrassinin. It has been shown to have anti-cancer effects, at least in part through inhibition of NF-kappaB and Akt signaling pathways. I3C may undergo a condensation reaction in vivo, leading to the...
Keywords: | 1H-Indole-3-methanol, 3-hydroxymethyl Indole, 3-Indolylmethanol, I3C, Indinol, NSC 525801, 1H-indole-3-methanol |
Application: | Myrosinase product, Anticancer compound |
CAS | 700-06-1 |
MW: | 147.2 D |
From 27.00€
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Item number: Cay10173-25
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty...
Keywords: | (±)14,15 EEQ, (±)14,15-epoxy Eicosatetraenoic Acid, (±)14,15-epoxy-5Z,8Z,11Z,17Z-eicosatetraenoic acid |
Application: | Bioactive lipid assays |
CAS | 131339-24-7 |
MW: | 318.5 D |
From 65.00€
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Item number: Cay31107-25
2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog. It inhibits spasms induced by pentylenetetrazole (PTZ, Cay-18682) and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor...
Keywords: | 2-[(3-methylbutyl)amino]-1,4-naphthalenedione |
Application: | Vitamin K analog |
CAS | 1607447-79-9 |
MW: | 243.3 D |
From 60.00€
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