SIRT4 (human recombinant)

SIRT4 (human recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10317-100 100 µg -

6 - 10 business days*

642.00€
 
There are seven human sirtuins, also known as class III HDACs, which have been designated... more
Product information "SIRT4 (human recombinant)"
There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1-SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and ADP-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase (GDH). In caloric-sufficient conditions, SIRT4 ADP-ribosylates GDH, repressing its activity and correspondingly decreasing insulin secretion. There is some uncertainty about the relevance of sirtuin ribosyl transferase activity due to its very slow rate, which is about 500 times lower than the corresponding deacetylation reaction (for those that have been characterized). SIRT4 is found in many tissues, but is specifically enriched in the kidney, heart, brain, and liver. Synonyms: NAD-dependent ADP-ribosyltransferase Sirtuin 4, Silent Information Regulator 4, SIR2L4, SIR2-like Protein 4, Sirtuin 4. Purity: >95% estimated by SDS-PAGE. Source: Recombinant N-terminal GST-tagged enzyme expressed in E. coli. Amino Acids: 1-314 (full-length). MW: 61.9 kDa. UniProt Accession #: Q9Y6E7.
Keywords: SIR2L4, SIR2-like protein 4, SIR2-like protein 4, Regulatory protein SIR2 homolog 4, Regulatory protein SIR2 homolog 4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-
Supplier: Cayman Chemical
Supplier-Nr: 10317

Properties

Application: WB
Conjugate: No
Host: E.coli
MW: 61,9 kD
Purity: >95% estimated by SDS-PAGE

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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