Elesclomol is an inducer of apoptosis and a copper ionophore. It induces the production of reactive oxygen species (ROS) and increases oxidative stress response gene expression in Ramos (RA 1) B cell lymphoma cells when used at a concentration of 500 nM. Elesclomol (100 nM) disrupts the mitochondrial membrane...

The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins,...

Low-density lipoproteins (LDL) is the major carrier of cholesterol in the blood, accounting for more than 60% of total plasma cholesterol. LDL is taken up by hepatic and extrahepatic tissues through LDL receptor-mediated endocytosis where it is internalized and degraded to free cholesterol and amino acids. Uptake of...