SIRT2 Direct Fluorescent Screening Assay Kit

SIRT2 Direct Fluorescent Screening Assay Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay700280-96 96 wells -

6 - 10 business days*

467.00€
 
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class... more
Product information "SIRT2 Direct Fluorescent Screening Assay Kit"
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) that catalyze a reaction coupling lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose. Cayman's SIRT2 Direct Fluorescent Screening Assay provides a fluorescence-based method for screening SIRT2 inhibitors or activators. The procedure requires only two easy steps, both performed in the same microplate. In the first step, the substrate, which comprises the p53 sequence Gln-Pro-Lys-Lys(epsilon-acetyl)-AMC, is incubated with human recombinant SIRT2 along with its cosubstrate NAD+. Deacetylation sensitizes the substrate such that treatment with the Developer in the second step releases a fluorescent product.License: Sold under license from Cyclex..
Keywords: SIRT2, SIR2L, EC=3.5.1.-, SIR2-like protein 2, NAD-dependent deacetylase sirtuin-2
Supplier: Cayman Chemical
Supplier-Nr: 700280

Properties

Application: SIRT2 assays, inhibitor screening, activator screening
Species reactivity: human
Format: Homog.

Database Information

KEGG ID : K11412 | Matching products
UniProt ID : Q8IXJ6 | Matching products

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H227, H315, H317, H319, H334, H335, H373
P Phrases: P210, P260, P261, P264, P271, P272, P280, P284, P302+352, P304+340, P304+341, P305+351+338, P312, P314, P321, P332+313, P333+313, P337+313, P342+311, P362+364, P370+378, P403, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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