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Item number: AG-40A-0093T-C010

SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Protein function: Acts as a negative regulator of the Toll-like and IL-1R...

Keywords:	TIR8, SIGIRR, Toll/interleukin-1 receptor 8, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single...
Application:	Bioassays
Expressed in:	Human cells
Origin:	human
MW:	~50 kD

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