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SET8 (human recombinant)

ART NR.: Cay10319-25 (25 µg)
Cay10319-50 (50 µg)
Cay10319-100 (100 µg)

Hersteller: Cayman

Datenblatt

Anwendungen: Enzyme kinetics

MW: 21 kD

Reinheit: >95%

UniProt ID: Q9NQR1
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Schlagworte: N-lysine methyltransferase SETD8, Histone-lysine N-methyltransferase SETD8, EC=2.1.1.43

25 µg

107 €

50 µg

203 €

100 µg

384 €

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Bemerkungen: Source: recombinant N-terminal Histidine-tagged SET8 amino acids 190-352, purified from E. coli, NP-065115. Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated. SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation. SET8 is also a novel regulator of p53, mono-methylating lysine 382 of the tumor suppressor. SET8's ability to suppress p53 transcriptional activity implies that it may play a significant role in tumorigenesis.

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