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1 Treffer SETD8; histone-lysine N-methyltransferas...print
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Cay10319-100
SET8 (human recombinant)
Cayman
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100 µg

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384 €

SET8 (human recombinant)


Enzyme kinetics Erklärungen der Abkürzungen ansehen.

Source: recombinant N-terminal Histidine-tagged SET8 amino acids 190-352, purified from E. coli, NP-065115. Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated. SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation. SET8 is also a novel regulator of p53, mono-methylating lysine 382 of the tumor suppressor. SET8's ability to suppress p53 transcriptional activity implies that it may play a significant role in tumorigenesis.

MW: 21 kD
Purity: >95%

UniProt ID: Q9NQR1

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Products for: SETD8 - histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]



Schlagworte:
N-​lysine methyltransferase SETD8, Histone-​lysine N-​methyltransferase SETD8, EC=2.1.1.43

 


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