Kontakt 0800-2466651 DE | EN Merkliste Login Warenkorb


Suche
zurück

SET8 Methyltransferase Inhibitor Screening Assay Kit

ART NR.: Cay700350-96 (96 wells)

Hersteller: Cayman

Datenblatt



MSDS

Anwendungen: SET8 inhibitor screening

Messtechnik: Fluorometric

UniProt ID: Q9NQR1
Suche mit UniProt ID

Schlagworte: KMT5A, SETD8, PR-Set7, PR/SET07, EC=2.1.1.-, EC=2.1.1.43, H4-K20-HMTase SETD8, Lysine N-methyltransferase 5A, SET domain-containing protein 8, N-lysine methyltransferase SETD8, PR/SET domain-containing protein 07

Cay700350-96

96
wells

530 €

In Warenkorb aufnehmen


Bemerkungen: Caymans SET8 Methyltransferase Inhibitor Screening Assay provides a convenient method for screening human SET8 inhibitors. The transfer of the methyl group from SAM by SET8 to the acceptor peptide (H4K20) generates S-adenosylhomocysteine, which is rapidly converted to S-ribosylhomocysteine and adenine by adenosylhomocysteine nucleosidase. This rapid conversion prevents the buildup of adenosylhomocysteine and its feedback inhibition on the methylation reaction. Finally, the adenine is converted to hypoxanthine by adenine deaminase, which in turn is converted to urate and hydrogen peroxide (H2O2). The reaction between H2O2 and 10-acetyl-3,7-dihydroxyphenoxazine (ADHP) produces the highly fluorescent compound resorufin. Resorufin fluorescence is analyzed using an excitation wavelength of 530-540 nm and an emission wavelength of 585-595 nm.
Image Art Cay700350-96 Cayman SET8 Methyltransferase Inhibitor Screening Assay Kit

Verwandte Produkte

    Products for: SETD8 - histone-lysine N-methyltransferase SETD8 [EC:2.1.1.43]

    Die Preise verstehen sich exkl. Versandkosten, eventuell anfallender Kühlmittelpauschale sowie der jeweils geltenden Mehrwertsteuer.





    alle Treffer anzeigen (87 INFOS)

     


    Forschungsprodukte im Fokus

     

    Produkte

    Service

    Company

    € 10 Gutschein sichern