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SET7/9 (human recombinant)

ART NR.: Cay10320-50 (50 µg)
Cay10320-100 (100 µg)

Hersteller: Cayman

Datenblatt



MSDS

Anwendungen: Enzyme kinetics

MW: 43 kD

Reinheit: >95%

UniProt ID: Q8WTS6
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Schlagworte: Histone-lysine N-methyltransferase SETD7, EC=2.1.1.43, KMT7, SETD7/9, SET Domain-containing Protein 7/9

Cay10320-50

50 µg

72 €

Cay10320-100

100 µg

137 €

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Bemerkungen: Source: recombinant N-terminal hexahistidine-tagged SET7/9 amino acids 1-366, purified from E. coli. Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase. SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10. Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation. SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.

Verwandte Produkte

    Products for: SETD7 - histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]

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