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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
029606.10 | 10 µg | - | - |
3 - 19 business days* |
1,371.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The SCF complexes represent the largest family of ubiquitin-protein ligases and mediate the... more
Product information "SCFFbw7 Complex, Active, Recombinant, Human (SCFFbxw7, SCFhCdc4)"
The SCF complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFFbw7 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell division, growth and differentiation, including Cyclin E1, c-Myc, Notch and c-Jun. Mutations have been found in the Fbw7 subunit of SCFFbw7 in various types of human cancers, therefore Fbw7 is considered to be a potent tumour suppressor. Source: Recombinant corresponding to complex of N-terminal GST-tagged, recombinant human Fbw7 full length, N-terminal 6His-tagged, recombinant human Skp1 full length, N-terminal 6His-tagged, recombinant human Cul1 full length and untagged recombinant human Rbx1 full length, co-expressed by baculovirus in Sf21 insect cells. Molecular Weight: Fbw7: ~107kD, Skp1: ~21kD, Cul1: ~93kD, Rbx1: ~12kD, Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | hAgo, FBW7, hCdc4, FBXW7, SEL-10, F-box protein FBX30, Archipelago homolog, F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7 |
Supplier: | United States Biological |
Supplier-Nr: | 029606 |
Properties
Conjugate: | No |
Species reactivity: | human |
Format: | Highly Purified |
Database Information
KEGG ID : | K10260 | Matching products |
UniProt ID : | Q969H0 | Matching products |
Gene ID | GeneID 55294 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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